I am not sure what you are talking about.
- First there is the location of the sims you have installed and the SDKs associated with them. They can be anywhere on your computer and provided you installed them correctly ADE will be able to find where they are via the Wizard. you need these to be correct to open stock airports
- Second is the location of ADE itself. That can be in any drive on your computer
- Third is the location you use to store ADE projects you are working on. Again you have a lot of flexibility in deciding where store then and where to compile them. You can set a default path for all projects or set them individually. ADE will default for you if you don't offer one and that is in the relevant projects folder in ADE.
This is the part of the wizard to find the paths to your simulator and SDK:
Click the Find button to have ADE look for the paths. Do it this way. ADE uses the registry. The only reason this will fail is if your installation is not correctly registered in the registry
This is the page in Settings you can use to define your default paths for saving projects, compiling and so on
You can see that ADE will suggest some depending on which version for the sim you are working with. You can set them differently if you wish. Just remember where they are
Finally, and this is for advanced users, You can set project specific paths. These only apply to that project
To keep it simple install ADE where you want. Run the New User Wizard and let ADE find the paths to sim and SDK. Check the default project paths in Options > Settings > Projects and stick with the defaults but make a note of what they are since otherwise you may not be able to find a project. If you can't then try Project > Find from the main menu