I'm using the amazing ADE application with Windows 10 and it works great! I didn't face any problem in this domain since I installed the latest version of .NET Framework 4.6.1 already. You can download it via Microsoft official website, then you need to activate it.
To activate .NET Framework:
1- Insert your Windows 10 DVD.
2- Run "cmd.exe" as administrator.
3- Type the following command in "cmd.exe": Dism.exe /online /enable-feature /featurename:NetFX3 /All /Source:E:\sources\sxs /LimitAccess
It should be activated like that. You should not face any problem with .NET Framework anymore!